Once upon a time, a fireman Todd used to work with when we first moved to Virginia had an Old English Sheepdog with one blue eye and one brown. His name was Bubba and he was the best dog in the world. I fell in love and was heartbroken when Bubba died a couple years ago of old age.
Fast forward to the present.
This same fireman's dog, another Old English Sheepdog, had puppies. One puppy out of 9 had one blue eye and one brown eye.